BBa_M12072 1 BBa_M12072 CueR internal copper sensor 2010-05-11T11:00:00Z 2015-05-08T01:13:55Z Yersinia pseudotuberculosis genome. http://www.ncbi.nlm.nih.gov/gene/2955378 Information on function from JL Hobman, J Wilkie, NL Brown. "A design for life: prokaryotic metal-binding MerR family regulators." Biometals, 2005. http://www.springerlink.com/content/u7732202161l4847/ CueR is a copper-sensitive activator/repressor found in Yersinia pseudotuberculosis which performs a task for copper similar to that performed by merR for mercury. In absence of copper, it represses the transcription of the genes downstream of it (in source, cueTPAD), but when bound to copper it causes underwinding of cueOP DNA and thus promotes RNA polymerase transcription of the region. In the source genome, the following sequences are copper coping mechanisms. Any genes inserted downstream of cueR will be transcribed only in the presence of copper inside the cell. Usable in E. coli and various other bacteria. false false _548_ 0 6722 9 Not in stock false none false Will Whitney BBa_M12072_sequence 1 atgaacattagcgatgttgcgaaaaaaaccggtttaaccagcaaagccattcgtttttatgaagaaaaaaaactggtgacgccacctgttcgcacggataacggttatcgcagctacacggccaaacatattgaagagctcacgttgctgcgccaggcgcggcaagtgggttttacactggatgagtgtcgtgaattgctggcattatttcataacccagcacggcacagcgcggatgtgaaagcggcaacattgctaaaagtagcggaaatcgagcaacatattaatgatttgaatcagatgcgtatgcgtttgttagcgttggcagaagagtgcccaggggatgagggcgcagattgcccaattattaatagcctggcgggatgttgccactcaagcagttcgctaccattaaaataa igem2sbol 1 iGEM to SBOL conversion Conversion of the iGEM parts registry to SBOL2.1 Chris J. Myers James Alastair McLaughlin 2017-03-06T15:00:00.000Z