BBa_I712083

BBa_I712083 Version 1

Component

Source: http://parts.igem.org/Part:BBa_I712083

Generated By: https://synbiohub.org/public/igem/igem2sbol/1

Created by: Marko Bitenc

Date created: 2007-10-21 11:00:00

Date modified: 2015-08-31 04:07:46

CMV promoter - CD4 (shortened) - TEV C

Details

• Types: DnaRegion
• Roles: Composite; engineered_region
• Sequences: BBa_I712083_sequence (Version 1)

Description

Human CD4 shortened receptor fused with C-terminal half of TEV protease and Myc tag. This construct is under control of CMV promoter.

Notes

CD4 (shortened) is also fused with C-terminal half of TEV protease. This construct is coexpressed with CCR5 receptor fused with N-terminal half of TEV protease (in mammalian cells). When that kind of human cells are infected with HIV virus both halves of TEV protease assemble and split protein regains its function. This principle can be used for fighting HIV infection.

Source

Human CD4 is a member of the immunoglobulin superfamily.

Components

Access	Instance	Definition
public	BBa_I712082	BBa_I712082
public	BBa_I712078	BBa_I712078

Sequence Annotations

Sequence Annotation	Location	Component / Role(s)
BBa_I712082	1,1907	BBa_I712082
BBa_I712078	1916,2290	BBa_I712078

Other Properties

• igem#experience: Works
• igem#sampleStatus: It's complicated
• igem#status: Planning
• synbiohub#ownedBy: user/james
• synbiohub#ownedBy: user/myers
• synbiohub#topLevel: BBa_I712083/1

Member of these Collections

• iGEM Parts Registry