| Types | DnaRegion
|
| Roles | CDS
Coding
|
| Sequences | BBa_K1039003_sequence (Version 1)
|
Description
In nature, serine integrases allow phages to integrate into the bacterial genome by site-specific recombination between attachment sites on the phage and bacterial genomes (attP and attB), both of which are between 30 and 60 bp depending which phage serine integrase is considered. Recombination between attP and attB leaves behind left and right attachment sites (attL and attR), which cannot be acted upon by Int alone. Thus, in the presence of Int alone, this recombination is irreversible (1).
Notes
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Source
Ghosh P, Kim AI, Hatfull GF. The orientation of mycobacteriophage Bxb1 inte- gration is solely dependent on the central dinucleotide of attP and attB. Molecular Cell 2003, 12:1101???1111.
