| Types | DnaRegion
|
| Roles | Coding
CDS
|
| Sequences | BBa_K1366109_sequence (Version 1)
|
Description
This part allows the production of a recombinant pIII protein linked with a pep42 peptide. This peptide change the tropism of the virus M13 and enables it to bind to a receptor called GRP78 that it is highly present in cancer cells. The binding between pep42 and GRP78 receptor allows the bacteriophage to penetrate the cancer cells and this initiates the transfection of DNA mediated with bacteriophages.
Notes
The structure of this construct is pIII linked with a pep42 peptide
Source
We used the DNA sequence of the PIII protein that is reported in NCBI
