Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Yijie Lai
Date created: 2016-10-07 11:00:00
Date modified: 2016-10-08 09:05:47
CUP1 promoter
| Types | DnaRegion |
| Roles | promoter Regulatory |
| Sequences | BBa_K1969005_sequence (Version 1) |
Description
This is the full length of CUP1 promoter in yeast Saccharomyces cerevisiae. As the major copper-activated metallothionine in yeast, Cup1p binds and sequesters cuprous copper(I), Cu+, providing the principal method of removing this metal ion from the cell. CUP1 transcription is specifically induced by the copper-dependent transcription activator Cup2p (more commonly known as Ace1p) in response to high levels of copper ions and by Hsf1p in response to heat shock, glucose starvation and oxidation stress. In the presence of copper, Cup1p is also capable of antioxidant activity and thus contributes a significant, albeit minor, role to oxygen radical detoxification, especially in the absence of Cu,Zn-superoxide dismutase Sod1p.Notes
As the promoter sequence is rather short, we may use recombinase to inset it upstream different coding sequence to control the expression level.Source
The genomic sequence from Saccharomyces cerevisiae.| Sequence Annotation | Location | Component / Role(s) |
| CUP1 promoter | 1,235 | feature/promoter promoter |