Source:
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Jaeyoung Jung
Date created: 2016-10-13 11:00:00
Date modified: 2016-10-25 01:41:45
Phosphoribosylaminoimidazole carboxylase catalytic subunit
| Types | DnaRegion |
| Roles | promoter Regulatory |
| Sequences | BBa_K2062000_sequence (Version 1) |
Description
Function: phosphoribosylaminoimidazole carboxylase catalytic subunitThis carboxylase is an enzyme involved in nucleotide biosynthesis, particularly in purine biosynthesis. It catalyzes the conversion of AIR (5???-phosphoribosyl-5-aminoimidazole) into CAIR (5???-phosphoribosyl-4-carboxy-5-aminoimidazole).
5-aminoimidazole ribonucleotide + CO2 5'-phosphoribosyl-4-carboxy-5-aminoimidazole + 2 H+
AIR synthetase is the fifth enzyme in the de novo synthesis of purine nucleotides. It catalyzes the reaction to form 5-aminoimidizole ribonucleotide (AIR) from formylglycinamidine-ribonucleotide FGAM. This reaction closes the ring and produces a 5-membered imidazole ring of the purine nucleus (AIR):