RUNX2

BBa_K415501 Version 1

Component

Source:
http://parts.igem.org/Part:BBa_K415501
Generated By: https://synbiohub.org/public/igem/igem2sbol/1
Created by: Laura Deming, Joy Jiao, Adrian Slusarczyk
Date created: 2010-10-23 11:00:00
Date modified: 2015-05-08 01:12:27

RUNX2 L1L2 MammoBlock Entry Vector



Types
DnaRegion

Roles
Coding

CDS

Sequences BBa_K415501_sequence (Version 1)

Description

RUNX2, or runt-related transcription factor, is a master osteoblast differentiation transcription factor; it is a downstream target of BMP-2 and switches on transcription of multiple effectors of osteoblast development. NCBI page with sequence, gene information etc. http://www.ncbi.nlm.nih.gov/gene/860

Isoforms: There are three isoforms of RUNX2 in humans, this part contains isoform Type-II, alpha, which is the longest and includes the 3' exon.

Notes

We wanted to use the longest RUNX2 isoform; this isoform has been shown to induce bone differentiation when transfected into human cells.

Source

Obtained as an L1L2 Entry vector from Open Biosystems.

Sequence Annotation Location Component / Role(s)
RUNX2 cDNA
21,1605
CDS feature/protein
igem#experience
None
 
igem#sampleStatus
It's complicated
igem#status
Planning
 
synbiohub#ownedBy
user/james
 
synbiohub#ownedBy
user/myers
 
synbiohub#topLevel
BBa_K415501/1